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Trovafloxacin mesylate

Name: Trovafloxacin mesylate
Brand: TargetMol
SKU: T13231L
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13231L Copy Product Info

Purity: 99.18%

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Trovafloxacin mesylate is a fluoroquinolone antibiotic and a dual inhibitor of DNA gyrase and topoisomerase IV, as well as a selective inhibitor of the Pannexin 1 channel (IC50 = 4 μM). With oral bioactivity and cell permeability, Trovafloxacin does not inhibit connexin 43 or PANX2, and is used for antibacterial therapy.

Cas No. 147059-75-4

Pack Size	Price	USA Stock	Global Stock
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$385	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.18%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Trovafloxacin mesylate is a fluoroquinolone antibiotic and a dual inhibitor of DNA gyrase and topoisomerase IV, as well as a selective inhibitor of the Pannexin 1 channel (IC50 = 4 μM). With oral bioactivity and cell permeability, Trovafloxacin does not inhibit connexin 43 or PANX2, and is used for antibacterial therapy.
Targets & IC50	Pneumococcal isolates:0.125 μg/mL (MIC), PANX1:4 μM, pneumococcus:0.06-0.25 mg/mL (MIC)
In vitro	Methods:3D bioprinted human primary liver tissue (containing hepatocytes, endothelial cells, and hepatic stellate cells) and 2D primary hepatocytes were used. Trovafloxacin mesylate was administered daily at 0.1–100 μM for 7 consecutive days. Toxicity was assessed through ATP, albumin, LDH detection, and histological staining. Results: Trovafloxacin mesylate caused dose-dependent damage to 3D liver tissue at clinically relevant doses, reduced albumin and ATP levels, induced hepatocyte necrosis, and showed significantly weaker toxicity in 2D hepatocytes compared to the 3D model. [1] Methods: A 3D bioprinted liver lobule model (containing human adipose mesenchymal stem cell-derived hepatocyte-like cells, umbilical vein endothelial cells, and hepatic stellate cells) was used. Cells were incubated with 0.22–407.80 μM Trovafloxacin mesylate for 24 h. Toxicity was assessed through cell viability, LDH, and cytochrome P450 reductase activity detection. Results: Trovafloxacin mesylate induced hepatotoxicity in a dose-dependent manner. The tri-cellular co-culture model was more sensitive, with EC50 of 1.04 μM, lower than the 5.45 μM of the single hepatocyte model. [2]
In vivo	Methods:C57BL/6 male mice were used to establish a controlled cortical impact brain injury model. Trovafloxacin mesylate was dissolved in DMSO + saline and administered by intraperitoneal injection at 60 mg/kg at 1, 24, and 48 h post-injury, with continuous observation for 6 days. Results: It significantly reduced brain injury markers, blood-brain barrier leakage, and pro-inflammatory factor levels, decreased inflammatory cell infiltration, improved motor function deficits, and exerted neuroprotective and anti-inflammatory effects. [3]

Chemical Properties

Molecular Weight	512.46
Formula	C₂₁H₁₉F₃N₄O₆S
Cas No.	147059-75-4
Smiles	CS(O)(=O)=O.[H][C@@]12CN(C[C@]1([H])[C@H]2N)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)-c1ccc(F)cc1F
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (234.16 mM), Sonication and heating to 60℃ are recommended.

H2O: 18 mg/mL (35.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9514 mL	9.7569 mL	19.5137 mL	97.5686 mL
5 mM	0.3903 mL	1.9514 mL	3.9027 mL	19.5137 mL
10 mM	0.1951 mL	0.9757 mL	1.9514 mL	9.7569 mL
20 mM	0.0976 mL	0.4878 mL	0.9757 mL	4.8784 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0390 mL	0.1951 mL	0.3903 mL	1.9514 mL
100 mM	0.0195 mL	0.0976 mL	0.1951 mL	0.9757 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Trovafloxacin mesylate chemical structure | Trovafloxacin mesylate in vivo | Trovafloxacin mesylate in vitro | Trovafloxacin mesylate formula | Trovafloxacin mesylate molecular weight